Richarlison is banned for the Premier League opener after throwing a flare into the stands while celebrating a goal in his latter days at Everton.
Likewise, Yves Bissouma may not be risked from the start having tweaked his hamstring. The new midfielder also missed a portion of pre-season due to Covid-19.
Clement Lenglet, Fraser Forster and Djed Sence are most likely to be kept on the bench for the visit of Saints, Emerson Royal being favoured over Spence at right wing-back if Matt Doherty is not risked on his return from knee surgery.
Oliver Skipp is Tottenham’s final absentee due to a gashed leg.
Predicted Tottenham XI: Lloris; Romero, Dier, Davies; Doherty, Hojbjerg, Bentancur, Sessegnon; Kulusevski, Kane, Son.