White has yet to feature in Qatar and missed the 3-0 Group B win over Wales on Tuesday night due to illness.
It is too late for the Three Lions to name a replacement for the versatile centre-back, so Gareth Southgate will be down to 25 players for the remainder of the World Cup.
A statement released by England on Wednesday evening read: “Ben White has left England’s training base in Al Wakrah and returned home for personal reasons.
“The Arsenal defender is not expected to return to the squad for the remainder of the tournament.
“We ask that the player’s privacy is respected at this moment in time.”